Impossible to answer without knowing a single thing beyond your server version.
That said, Exchange 2013 tends to require Authentication, and the email address tends to have to be valid.
It also tends to require SHA-2 support, which this device doesn't do according to the limitations listed at left.
The port is normally 587 (TLS/STATTLS) or 25, 2525 is not a default, it is only really used to bypass a firewall rule.
Best bet is to verify settings via Telnet by sending an email from the command line, if you can't do it using nothing but the IP and port of the server, neither can the printer.